In a study conducted by Wang et al. [99] on mice receiving proinflammatory and antioxidative liposaccharide, it was observed that apart from improving cerebral antioxidative status, lycopene can also mitigate inflammations occurring in the nervous system, amylogenesis and cognitive impairment, most likely by mediating the signal pathways for MAPK (mitogen-activated protein kinases), nuclear factor κB, and Nrf2 (nuclear factor-erythroid 2-related factor 2). Here, NFE2L2 is linked to Cognitive impairment.