PLA2R1 and myocardial ischemia: However, sPLA2-IIA might not be the only one in the family, since recent evidence in a model of myocardial ischemia has pointed out that other isoforms, sPLA2-IB and sPLA2-IIE and its receptor PLA2R1, might mediate collagen-dependent biological effects in the infarcted myocardium [31].