To be confused with ME/CFS in the confirmatory tests of mitochondrial respiratory function and TORC1 activity, other illnesses would not only need to cause reduced viability of frozen lymphocytes, they would also need to confer the same pattern of molecular abnormalities upon the derived lymphoblasts—decreased Complex V efficiency, elevated proton leak as a proportion of basal metabolic rate, as well as increases in maximum respiratory capacity, Complex I activity, nonmitochondrial oxygen consumption and TORC1 activity. The gene discussed is CRTC1; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.