Finally, in order to better understand the molecular changes associated with morphological and densitometric alteration after ELS challenges, Delpech and colleagues profiled the gene expression of hippocampal microglia in MS mice (brief daily separation model) immediately after the stress procedure, revealing perturbation of several genes, including an increased expression of genes involved in cell cycle regulation and apoptosis (e.g., CSF1, CSF3R), microglial activation, and anti-inflammatory function, and a reduced expression of several pro-inflammatory genes. Here, CSF1 is linked to myeloid sarcoma.