For the highly metastatic BL6-10 melanoma cells, it was further shown that RPM-exposure reduced the focal adhesions and altered the cytoskeleton and the nuclear positioning, leading to an enhanced cell apoptosis via suppression of the FAK/RoA-regulated mTORC1/NF-kB and ERK1/2 pathways [94]. This evidence concerns the gene PTK2 and melanoma.