Moreover, it was reported that random positioning on a three-dimensional clinostat (with 30°/s angular velocity) reduced BL6-10 melanoma cell proliferation, adhesion, and invasiveness in vitro and decreased tumor lung metastasis in vivo via FAK/RhoA-regulated mTORC1 and AMP-activated protein kinase pathways [93]. This evidence concerns the gene PTK2 and melanoma.