Interestingly, the hypergravity-induced increase in the RNA expression of tyrosinase (Tyr, a key enzyme of melanogenesis) in pigmented non-metastatic 1F6 melanoma cells was partly inversed after transfection of the cells with siRNA against the sGC-β1 subunit, suggesting a partial role of sGC-cGMP signaling in the hypergravity-induced pigmentation. This evidence concerns the gene SGCB and melanoma.