In LN-299 and U-118 MG human glioblastoma multiforme cells, ectopic overexpression of PODXL increased soluble/intracellular beta-catenin levels and induced mRNA expression of the beta-catenin signaling target genes c-MYC and c-JUN and cell proliferation through a mechanism dependent on p38 mitogen- and beta-catenin signaling [75]. This evidence concerns the gene CTNNB1 and glioblastoma.