Moreover, knockdown of the EMT activator ZEB1 using specific shRNAs in Granta-519 and/or Jeko-1 mantle cell lymphoma cell lines reduced cell viability, proliferation, and drug resistance and greatly diminished tumor growth in mouse xenograft models, indicating the mediation of ZEB1 in mantle cell lymphoma progression [114]. The gene discussed is ZEB1; the disease is mantle cell lymphoma.