PODXL and gastric cancer: Additionally, PODXL in SGC-7901 gastric cancer cells favored proliferation and colony formation, abrogated cell apoptosis, activated phosphatidylinositol 3-kinase (PI3K)/AKT, MAPK/ERK, and NF-kB signaling pathways, and promoted tumorigenesis in a mouse xenograft model through a mechanism dependent on RUN and FYVE domain containing 1 (RUFY1) [52].