Moreover, PODXL increased the level of inhibitory phosphorylation of glycogen synthase kinase-3B (GSK3B) via activation of p38 mitogen-activated protein kinase (MAPK), indicating that PODXL enhances glioblastoma multiforme proliferation by increasing the soluble beta-catenin level/beta-catenin signaling through a mechanism dependent on p38 MAPK/GSK3B pathway [75]. This evidence concerns the gene GSK3B and glioblastoma.