AKR/SUB were first identified in Drosophila melanogaster, Mus musculus, and Ixodes scapularis as transcription factors involved in the regulation of immune deficiency (IMD) and tumor necrosis factor (TNF)/Toll-like receptor (TLR)-nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) (TNF/TLR) signaling pathways, and developmental processes [12,13,14,15]. Here, TNF is linked to Immunodeficiency.