Another isoform of PPAR, PPAR-δ, is involved in dyslipidemia and activation of PPAR-δ by means of a selective agonist, referred to as seladelpar (MBX-8025), beneficially affected plasma lipid levels and showed favorable trends in insulin resistance and waist circumference in patients with dyslipidemia [132]. This evidence concerns the gene PPARA and Insulin resistance.