Although the role of PARP-1 and PARP-2 in modulating NK cell activity against tumors is largely unknown, the aforementioned function of PARP-1 in controlling NK cell recruitment to the site of viral infection [72,73] and its role in the downregulation of NK cell-activating receptor ligands to evade immune surveillance in acute myeloid leukemia [74], may impact tumor progression. This evidence concerns the gene PARP2 and neoplasm.