TP53 and Li-Fraumeni syndrome: Germline PV/LPVs in the TP53 gene are associated with Li-Fraumeni syndrome (LFS), a rare autosomal dominant disorder characterized by a high predisposition to several types of cancer, such as brain tumors, sarcomas, acute leukemia, and adrenocortical tumors [25,62,63,64,65,66,67,68,69].