NBN and breast cancer: Germline variants in these three genes have also been associated with an increased risk of BC/OC [137,198,199,200,201]; in particular, the NBN gene, located on chromosome 8q21.3, which encodes the Nibrin protein, also known as p95 and NBS1 [202], which is responsible for the localization of the complex and for the interactions with other DSB-signaling and DNA-repair proteins [197].