TP53 and breast cancer: Moreover, in 2018, a systematic review of The Cancer Genome Atlas (TCGA) data was performed, focusing on pathogenic germline variants: besides the BRCA1 and BRCA2 genes, PV/LPVs in ATM, PALB2, RET, NF1, TP53, BUB1B, MAX, and APC genes have been detected in BC patients, and PV/LPVs in ATM, PALB2, TP53, NF1, and SDHA genes have been detected in OC patients [267].