When considering expression data for the three overlapping snoRNA/host gene couples mentioned above, only the SNORA63/EIF4A2 turned out to be over-expressed in squamous cell carcinomas of head and neck and of the lung, suggesting either that in most cancer types snoRNA/host gene CNA is an early event in tumor development, and expression of the two is first boosted, and later on is shut down, or alternatively that amplification of SNORA63/EIF4A2 is a passenger event, consequent to the proximity to other cancer driver genes in the chromosome. This evidence concerns the gene EIF4A2 and cancer.