All these genes map to the same chromosomal location, 3q27, which also hosts different oncogenes (like TERT, PI3KCA, and BCL6) and has been shown to be frequently amplified in squamous cell carcinomas with different localizations (lung [44], esophagus [45], mouth [46]), in lymphomas [47], and in lung cancers different from LUSC (i.e., small cell lung carcinomas and adenocarcinomas [48]). Here, BCL6 is linked to adenocarcinoma.