The role of Ca2+ signaling through the SOCE pathway involving STIM1 and ORAI1 has been reported previously to affect the prognosis of cervical, colorectal, breast, esophageal, multiple myeloma, and lung cancers by affecting tumor growth, proliferation, metastasis, and survival [3,32,33,34]. The gene discussed is ORAI1; the disease is lung carcinoma.