Wang et al. reported similar results in lung cancer by exposing A549 cells to high nicotine levels, which in turn resulted in increased HIF-1α levels (as shown previously by Guo et al. [74]), leading to the upregulation of SOCE components, namely ORAI1, TRPC1, and TRPC6 [75]. The gene discussed is TRPC1; the disease is lung carcinoma.