MAPT and early-onset autosomal dominant Alzheimer disease: Finally, as advanced age is approached, the concomitant tendency toward the increase of the Gibbs free energy is most likely due to protein aggregation processes, which reduce entropy and may reflect a functional deterioration of this organ as is the case with virtually all neurodegenerative diseases whose hallmarks include amyloid aggregation, but not only; for example, pathologies such as tauopathy in Alzheimer’s disease also involve function-reducing tangles composed of MAP-tau.