Serum CFH, CUL5, PKCE, APOA4, APOE, CCDC171, CCDC43, VIL1, antigen KI-67, NKRF, APPBP2, CAPRI, C1QC, C1S, C4, C5, C8A, C8B and MBL2 concentrations were two to three times elevated in patients with CKD. The gene discussed is RASA4; the disease is chronic kidney disease.