On the other hand, the altered DNA methylation of both GPR55 and CB1 encoding genes, resulting in increased expression of GPR55 and reduced levels of the CB1 in CRC patients [58], also supports the hypothesis that the ES receptors could behave either as tumour promoting or tumour suppressor genes depending on the kind of epigenetics changes they undergo. This evidence concerns the gene GPR55 and colorectal carcinoma.