SLC9A1 and breast cancer: It is also been demonstrated that NaV1.5-Na+ channels are in a close association with NHE-1, both being overexpressed in BC, where they contribute together to degrade the tumoral microenvironment, stimulate the formation of invadopodia and foster the metastatic process in a similar manner that CPR does [54,74,75,76,149] (Table 1).