SOD1 and amyotrophic lateral sclerosis: The complement deposition (C1q, C3b/iC3b, and C5b-9 factors) in proximity of the neuromuscular junction, motor neuron terminals, and near the Schwann cells occurs early, also in presymptomatic stages, both in human ALS patients and in transgenic SOD1 mice [192,193], leading to a peripheral axonopathy that precedes the central neuronal death.