TLR4 and Alzheimer disease: A wide range of therapeutic compounds (Table 3) have demonstrated their efficacy in animal models of AD-like pathologies, mainly by inhibiting TLR4 expression, suppressing microglial activation and pro-inflammatory cytokine levels, ameliorating learning and memory functions, inhibiting oxidative stress, and reducing apoptotic cell death and Aβ load (number and size of Aβ deposit) [120,121,122,123,124,125,126].