Either systemic [11] or intratumoral [2] IL-27 treatments eliminate tumors without toxicity, and mostly the anti-tumor mechanisms have been shown to be indirect, including induction of cytotoxic T lymphocyte responses or inhibition of angiogenesis through induction of chemokine (C-X-C motif) ligand (CXCL)9-10 [11]. This evidence concerns the gene IL27 and neoplasm.