MAPK8 and melanoma: For instance, RAF inhibitor resistant melanoma cells can upregulate the expression of neuropilin-1 (NRP1), which uses the JNK pathway to induce the expression of receptor tyrosine kinases (RTKs), specifically epidermal growth factor receptor (EGFR/ERBB1) and insulin-like growth factor receptor 1 (IGFR1), that can bypass the signaling block imposed by RAF inhibition [75].