Jin et al. discovered that FBP1 could inhibit the interaction of the scaffold protein IQ-domain GTPase-activating protein 1 (IQGAP1) with ERK1/2, thereby hindering IQGAP1-mediated activation of ERK1/2 in pancreatic ductal adenocarcinoma (PDAC) cells [152]. The gene discussed is IQGAP1; the disease is pancreatic ductal adenocarcinoma.