In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model, mice showed severe motor deficit, loss of dopaminergic neurons, and increased α-synuclein; however, these phenotypes were reduced by inhibiting NLRP3 inflammasome activation [134]. This evidence concerns the gene NLRP3 and Parkinson disease.