Mice subjected to CLP exhibit hippocampal memory impairment in a fear conditioning test, damaged hippocampal structure, activation of the NLRP3/caspase-1 pathway, increased pyroptosis, and inflammatory cytokines such as IL-1β and IL-18; however, NLRP3 inhibition reversed these outcomes after CLP injury [62], suggesting the involvement of NLRP inflammasome in SAE-associated cognitive disorders. This evidence concerns the gene NLRP3 and Cognitive impairment.