Inflammasome-associated genes, including NLRP3, IL-1β, IL-18, caspase-1, GSDMD, and ASC, are increased in the postmortem brains of MS patients, and GSDMD is observed in the myeloid cells and oligodendrocytes of MS lesions, indicating pyroptosis. The gene discussed is CASP1; the disease is myeloid sarcoma.