Remarkably, UBQLN2 also participates in the disease with other ALS-related (and autophagy-related) proteins like VCP (valosin-containing protein) in the process of protein degradation associated with endoplasmic reticulum ERAD [137] and OPTN to modulate the assembly of specific endosomal vesicles [138]. This evidence concerns the gene OPTN and amyotrophic lateral sclerosis.