However, mutations in the SOD1 gene account only for 2% to 5% of ALS cases; the most frequently mutated gene is C9ORF72. Using AAV-5-miC, researchers managed to reduce the foci of nuclear RNA that generate toxicity in a murine model of mutant ALS for C9orf72 [186]. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.