Another approach that involves transcriptional modulation directly involves autophagy through the transcription factor HLH-30/TFEB, where it has been shown that by silencing the nuclear export protein XPO-1/XPO1 in a fly ALS model, proteostasis was improved and autophagy and longevity were increased, which was due to a decrease in the nuclear export of HLH-30, thus preventing neurodegeneration. This evidence concerns the gene XPO1 and amyotrophic lateral sclerosis.