A characteristic hallmark of several neurodegenerative diseases, including ALS, is the cytoplasmic translocation and formation of aggregates of various RNA-binding proteins such as TDP43, FUS, hnRNPA1 (heterogeneous nuclear ribonucleoprotein A1), hnRNPA2B1 (heterogeneous nuclear ribonucleoproteins A2/B1), and MATR3, which fulfill essential functions for RNA metabolism [63]. This evidence concerns the gene HNRNPA2B1 and neurodegenerative disease.