The top 10 hub genes include CDCA5, OIP5, TOP2A, PRC1, ASPM, NUSAP1, UBE2C, CDC20, CCNA2, and KIF20A. Cai et al. showed that CDC20, AURKB, BIRC5, RRM2, MCM2, PTTG1, CDKN2A, NEK2, CENPF, RACGAP1, GNA14, and CDCA5 are hub genes that may be important for diagnosis, clinical intervention, and prognosis of HCC [37]. Here, RRM2 is linked to hepatocellular carcinoma.