Because PKR has also been implicated in the anti-tumour activity of chemotherapeutic drugs such as doxorubicin (DOX) and etoposide [15,16], and nc886 has been identified as an interesting tumour suppressor [17,18,19], we consider the analysis of PKR and the nc886 in patients as potential predictive biomarkers to be of clinical importance. This evidence concerns the gene EIF2AK2 and neoplasm.