Table 2 depicts the annual rates of contralateral breast cancer when left censored at date of PV report. BRCA1 and BRCA2 PV carriers had lower annual rates of contralateral breast cancer (2.5% and 1.1%, respectively) compared to TP53 carriers (10.7%). The proportion with synchronous breast cancer were 0.0% for BRCA1 1.6% for BRCA2 and 5.3% for TP53. This evidence concerns the gene BRCA1 and breast cancer.