Similarly, E. coli K88 and mycotoxin zearalenone (ZEA) infection of IPEC-1 epithelial cell line was protected in the presence of mixed Lactobacillus strains (L. acidofilus ID11692, L. plantarum ID1253 and L. paracasei ID13239) by downregulating TLR-1, TLR-2 and TLR-4 gene expression [60]. This evidence concerns the gene TLR4 and infection.