In 2001, biallelic recessive mutations in PANK2 were revealed in PKAN.3 The mutations result in a decreased activity of pantothenic acid kinase 2, which is a key regulatory enzyme in coenzyme A production by pantothenic acid, possibly leading to the reduction of coenzyme A3 and accumulation of its substrates, cysteine, which may chelate iron accumulation.4 The reported prevalence was 1‐3/1 000 000,4 but the accurate prevalence of PKAN is unclear yet. Here, PANK2 is linked to pantothenate kinase-associated neurodegeneration.