When CD47 is overexpressed, phagocytosis mediated by macrophages is suppressed, promoting tumor progression resulting in worse OS in a wide variety of tumors.10 In this study, we evaluated CD47 expression by IHC in NSCLC tumor cells based on H‐score from EGFR FLEX trial and found an optimal cutoff ≥ 150.21 Tumor cells have shown an expression level of ≥1% in 84% of patients, of which 65.5% had an expression ≥50%; CD47 was not a prognosis factor that response to treatment or a longer survival. Here, EGFR is linked to non-small cell lung carcinoma.