TP53 and cancer: Species-specific cancer control mechanisms have been identified in individual species, such as increased TP53 copy number in elephants (Sulak et al., 2016), but we show here that investment is cancer control is key to longevity across the entire mammalian phylogeny because top enriched pathways for the 3L phenotype do not depend on a handful of species (Figure 1—figure supplement 3 and Figure 1—figure supplement 2).