COL4A1 and glaucoma: Herein, we describe a homozygous missense COL4A1 variant in 2 brothers, from a first-degree consanguineous Turkish family, both of whom have small vessel brain disease including small internal porencephaly, associated with eye defects such as retinal vessel tortuosity, Axenfeld-Rieger anomaly, cataract, and glaucoma.