The inheritance of COL4A1- and COL4A2-related disorders is dominant: In a recent study, the authors reported 44 new patients, 24 due to de novo mutations; they also calculated the number of previously reported COL4A1 and COL4A2 mutations to be 63 and 6, respectively.3 Eight of 44 COL4A1/COL4A2 mutations associated with epilepsy were de novo. Here, COL4A2 is linked to epilepsy.