BRCA1 and neoplasm: BRCA1 is responsible for encoding BRCA1 protein which consists of 1,863 amino acids, an N-terminal RING domain which binds with BARD1 to form a heterodimeric E3 ubiquitin ligase [3], a domain in the middle of the moiety interacting with DNA repair protein RAD51 [4], and a C-terminus containing two conserved BRCA1 C-terminal (BRCT) domains that mostly involve in tumor suppression, growth inhibition and transcription activation [5-7].