We have recently shown that YAP1 is expressed in CRC at an enhanced level.16 Suppression of YAP1 in CRC cell line, HCT116, caused downregulation of 288 genes, and those genes are involved in malignant proliferation and epithelial‐mesenchymal transition (EMT), suggesting that YAP1 targeting genes play an important role in progression of CRC. This evidence concerns the gene YAP1 and colorectal carcinoma.