Here, a Yes‐associated protein 1 (YAP1) target lncRNA LINC00152 is identified, and a critical role of YAP1/LINC00152/FSCN1 axis in the tumorigenesis of colorectal cancer (CRC) is revealed, which may provide a potential new target for CRC diagnosis and therapy. Here, FSCN1 is linked to colorectal cancer.