We next explore the mechanism for LINC00152 regulating the expression of FSCN1. LncRNAs can function as microRNA sponges in the cytoplasm or regulate gene expression in the nucleus as nuclear transcriptional regulators.23, 24 As shown in Figure S11 (Supporting Information), LINC00152 was mainly localized in the cytoplasm of CRC cells. This evidence concerns the gene FSCN1 and colorectal carcinoma.