Down-regulation of GLUT2 observed in the present study may be attributed to the impaired insulin sensitivity and the altered glucose metabolism due to the relative insulin deficiency induced by STZ; this is in accordance with El-Abhar & Schaalan(89), Al-Shaqha et al. (90) and Rathinam & Pari(91). The gene discussed is INS; the disease is hyperinsulinemic hypoglycemia, familial, 4.