Considering the key role of k-ras mutation in EGFR signaling pathway, detecting of k-ras mutations in ovarian carcinoma should stand in the center of attention again, owing to the role of k-ras mutation as a predictive biomarker in poor response to anti-EGFR monoclonal antibody therapies (3, 6, 14, 28, 29). The gene discussed is EGFR; the disease is ovarian carcinoma.