CCN2 and breast neoplasm: In previous work, we found that tranilast suppresses the expression of TGF-β target genes involved in collagen (e.g., COL1A1 and COL3A1) and hyaluronan synthesis (e.g., HAS2 and HAS3), as well as, other components of the extracellular matrix (ECM) such as connective tissue growth factor (CTGF) and lysyl oxidase (LOX) gene expression in breast tumors 36.