Here, we verified the tumor-suppressor role of ZNF750 in ESCC and elaborated on its possible mechanisms that ZNF750 directly bound to the promoter region of Snail Family Transcriptional Repressor 1 (SNAI1) and down-regulated the expression of SNAI1 to inhibit the epithelial-mesenchymal transition (EMT) of ESCC cells, in order to provide useful clues for clinical treatment of ESCC. The gene discussed is SNAI1; the disease is neoplasm.