Relevant in the scope of this review, they found H3K27ac super-enhancer marks (enhancer cluster regions) at the sox10 locus, which plays a key role in neural crest formation and melanomagenesis, suggesting an epigenetic mechanism to increase SOX10 expression leading to the reemergence of the neural crest progenitor state to initiate melanoma 23. The gene discussed is SOX10; the disease is melanoma.