DOT1L and cancer: Here, DOT1L promotes CRC stemness and tumorigenesis by inducing H3K79 methylation 6, but the underlying DOT1L target genes driving oncogenesis and CRC progression is unclear. SNAIL and ZEB1 are important transcription factors that regulate the epithelial-mesenchymal transition (EMT) and are associated with cancer-cell metastasis and invasion 18-20.