AKT1 and cancer: 10,11 Moreover, PI3K/AKT pathway has diverse downstream effects on reprogramming cellular metabolism, it could support the proliferation, survival and metastasis of cancer cells with its downstream network. 51 There are evidences that SREBP siRNAs (siSREBP1 and siSREBP2) could inhibit the progression and metastasis of PCa by repressing the PI3K/AKT signaling pathway. 8,9 Therefore, siSREBP1 could restore the sensitivity to prostate cancer of DTX and enhance the effects of reducing the progression and metastasis of prostate cancer by inhibition of PI3K/AKT when synergize with DTX.