Notably, MZF1 was highly expressed in NB tissues with elder age (P=8.1×10-5), death (P=1.3×10-6), or advanced INSS stage (P=2.1×10-4), and was associated with poor survival of patients (P=6.9×10-4 and P=5.8×10-3, Figure 1B-C, and Figure S2A) as an independent prognostic factor (hazard ratio=2.330, 95% confidence interval=1.021 to 3.317, P=0.044). The gene discussed is MZF1; the disease is neuroblastoma.