Importantly, administration of a cell-penetrating MZF1-uPEP or lentivirus over-expressing MZF1-uPEP was able to suppress aerobic glycolysis, tumorigenesis, and aggressiveness of NB cells, suggesting the crucial roles of MZF1-uPEP in repressing YY1/MZF1 axis in aerobic glycolysis and tumor progression. Here, YY1 is linked to neuroblastoma.