In HBCx-154 PDX (PIK3CA-mutated) the 3 compounds had similar anti-tumor activities, however inhibition of P-AKT and P-S6 was higher in xenografts treated by BAY-80-6946 and PF-04691502 compounds, suggesting that in this tumor inhibition of PI3K is necessary to inhibit PI3K-Akt signaling pathway. The gene discussed is RPS6; the disease is neoplasm.