PRRG4 and colorectal carcinoma: Further, Marshall et al. evaluated the performance of seven combined mRNA markers, namely annexin A3 (ANXA3), C-type lectin domain family 4 member D (CLEC4D), lamin B1 (LMNB1), proline-rich gamma-carboxyglutamic acid protein 4 (PRRG4), tumor necrosis factor alpha induced protein 6 (TNFAIP6), Vanin 1 (VNN1), and interleukin 2 receptor subunit beta (IL2RB) to diagnose CRC patients and achieved 0.80 AUC, 82% sensitivity, 64% specificity, and 73% accuracy [39].