Moreover, proteomic analysis of CRC EVs has revealed a number of unique protein markers, including epithelial cell adhesion molecule (EpCAM), cadherin-17, CEA, epidermal growth factor receptor (EGFR), mucin 13 (MUC13), keratin 18, CD147, CD9, and glypican 1 (GPC1) [20, 21]. This evidence concerns the gene GPC1 and colorectal carcinoma.