Furthermore, the “Gal-ratio” proposed in our previous study [25], represented the level of fucosylated galactosylation of IgG was significantly increased in PC group (P < 0.001)(Fig. 2d) and could be a moderately accurate marker for prediction of NACT efficacy (AUC (under area of ROC) = 0.776, 95% CI 0.633 to 0.919). Here, GAL is linked to pachyonychia congenita.