Among the three genes, ETV4 and ETV5 were derepressed, and ETV4 had the highest fold increase in both CIC KO HCT116 and HT29 cells (Fig. 4a), suggesting that the regulation of ETV4 expression might be most considerably dependent on CIC in CRC cells compared with those of ETV1 and ETV5. The derepression of ETV4 was also confirmed at protein levels in CIC KO CRC cells (Fig. 4b). This evidence concerns the gene ETV1 and colorectal carcinoma.