ETV4 and Familial prostate cancer: In most cases, CIC deficiency promotes cancer progression via derepression of PEA3 group genes, and the degree of derepression of each member of the PEA3 group genes is variable among cancer types: ETV5 is the most significantly and dramatically upregulated in CIC-deficient prostate cancer cells [36], while ETV4 is upregulated in liver cancer cells [37].