The PEA3 group factors are known as an oncogenic transcription factor, because the overexpression of these transcription factors promotes cancer cell proliferation and metastasis via activating the transcription of a subset of genes related to control of cell division and migration, such as matrix metalloprotease (MMP), vascular endothelial growth factor (VEGF), and telomerase reverse transcriptase (TERT) [38]. This evidence concerns the gene VEGFA and cancer.