PIM1 and acute myeloid leukemia: As referenced to in the introduction, there are several preclinical single-agent PIM kinase inhibitors available, but only a few have proceeded to phase I clinical trials, and been unsuccessful due to either a dose-limiting cardiac QTc prolongation (SGI-1776) [24] (NCT00848601) or lack of observed effect (AZD1208 in AML) [30, 57] (NCT01489722).