There is a significant enhancement of apoptotic induction observed in Fig. 3h, i in both BT-474 and HCC-1954 over the 3-h incubation in both IBL-302 and BKM120 as the therapeutic concentration increases; however, IBL-302 induces significantly more activation of caspase 3/7 when compared with BKM120 at similar concentrations (BT-474 (p < 0.0.027) and HCC-1954 (p < 0.041)). This evidence concerns the gene CASP3 and hepatocellular carcinoma.