Thus, the exposed hypusine residue might be a structural determinant needed for nuclear import of GLS2 through nuclear transport receptors or for specific interaction with nucleotides required in a putative transcriptional regulatory role, although further experiments will be needed to assess the functional relevance of this PTM in the GLS2 protein expressed in human cancer cells, as well as the role of the hypusination enzyme machinery in cancer growth and proliferation. Here, GLS2 is linked to cancer.