TFE3 and renal cell carcinoma: Given that both TFE3 and TFEB pertain to the microphthalmia-associated transcription factor family, Xp11 translocation RCCs and RCC associated with t (6; 11) (p2l; q12)/TFEB gene fusions were reclassified as MiT family translocation RCCs in the 2016 WHO renal tumour classification scheme5.