To examine the role of JMJD3 in global regulation of hepatic genes, including autophagy genes, JMJD3 was downregulated specifically in the liver by infection of JMJD3-floxed mice with hepatocyte-targeting AAV-TBG-Cre15,16 (Fig. 1a), and effects of the downregulation on global gene expression and H3K27-me3 levels were examined by RNA-seq and ChIP-seq, respectively. The gene discussed is SERPINA7; the disease is infection.