NOS3 and cancer: ASMA is an actin isoform that is upregulated in the tumor and promotes in cancer cells a metastatic activity associated to EMT71,72, MMP2 is a metalloproteinase that promotes metastatic growth by degrading basement membrane constituents73,74, whereas eNOS affects inflammation, angiogenesis, apoptosis, cell cycle, invasion, and metastasis75,76.