Furthermore, studies by Marneros et al. 2013 and 2016, demonstrate that Nlrp3−/− mice crossed with a VEGF-Ahyper strain (a strain known to exhibit age-dependent features of both wet- and dry-AMD), showed reduced numbers of CNV lesions compared to controls, however, did not exhibit any protection against RPE degeneration or macrophage infiltration35,36. Here, VEGFA is linked to dry age related macular degeneration.