NLRP3 and age-related macular degeneration: Although they demonstrate that the NLRP3 inflammasome can be activated in RPE by various stimulations such as oxidative stress19, accumulation of repetitive transposable elements of non-coding RNA (Alu RNA)22,32, or inflammatory pathway stimulants including drusen components lipofuscin31, C1q21, or Aβ-peptide 1–4027,28; they do not provide any conclusive evidence to show NLRP3 involvement in AMD disease progression.