In addition, research by Doyle et al., 2012 indicates that NLRP3 may play a protective or homeostatic role in wet-AMD pathogenesis21, showing using a laser-induced mouse model of CNV, that compared to WT controls, Nlrp3−/− mice displayed increased CNV development and subretinal hemorrhage as well as increased macrophage infiltration to lesion areas21. The gene discussed is NLRP3; the disease is wet macular degeneration.