Regardless, the inner retinal localization and upregulation of Nlrp3 demonstrated in this, and other works37,59, does not easily support an outer retina photoreceptor degeneration phenotype as seen in this model, and in AMD pathogenesis, additionally supporting the hypothesis that NLRP3 may not largely contribute to retinal degenerations. This evidence concerns the gene NLRP3 and age-related macular degeneration.