Furthermore, studies by Marneros et al. 2013 and 2016, demonstrate that Nlrp3−/− mice crossed with a VEGF-Ahyper strain (a strain known to exhibit age-dependent features of both wet- and dry-AMD), showed reduced numbers of CNV lesions compared to controls, however, did not exhibit any protection against RPE degeneration or macrophage infiltration35,36. The gene discussed is NLRP3; the disease is dry age related macular degeneration.